CATH Classification

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 1
Functional Family UDP-3-O-acyl-N-acetylglucosamine deacetylase

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P47205
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

P47205
LPXC_PSEAE
Pseudomonas aeruginosa PAO1
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 4LCG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
Liang, X., Lee, C.J., Zhao, J., Toone, E.J., Zhou, P.
J.Med.Chem.