CATH Classification

Domain Context

CATH Clusters

Superfamily C2 domain
Functional Family Kinase C alpha type

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P05696
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P05696
KPCA_RAT
Rattus norvegicus
Protein kinase C alpha type

PDB Structure

PDB 4L1L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cd(2+) as a ca(2+) surrogate in protein-membrane interactions: isostructural but not isofunctional.
Morales, K.A., Yang, Y., Long, Z., Li, P., Taylor, A.B., Hart, P.J., Igumenova, T.I.
J.Am.Chem.Soc.