1 keywords

CATH Domain 4l1bB02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.287 Helix Hairpins
Homologous Superfamily 1.10.287.1490  

Domain Context

CATH Clusters

Superfamily 1.10.287.1490
Functional Family Putative phosphatidylinositol 3-kinase regulatory subunit alpha

Enzyme Information

UniProtKB Entries (1)

P42336
PK3CA_HUMAN
Homo sapiens
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PDB Structure

PDB 4L1B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
Zhao, Y., Zhang, X., Chen, Y., Lu, S., Peng, Y., Wang, X., Guo, C., Zhou, A., Zhang, J., Luo, Y., Shen, Q., Ding, J., Meng, L., Zhang, J.
ACS Med Chem Lett