CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Cystathionine gamma-synthase homolog

Enzyme Information

2.5.1.48
Cystathionine gamma-synthase.
based on mapping to UniProt P56069
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.
-!- Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively. -!- In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia. -!- Formerly EC 4.2.99.9.

UniProtKB Entries (1)

P56069
METB_HELPY
Helicobacter pylori 26695
Cystathionine gamma-synthase

PDB Structure

PDB 4L0O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure determination of cystathionine gamma-synthase from Helicobacter pylori
Tarique, K.F., Rehman, S.A.A., Ahmed, E., Gourinath, S.
To be Published