CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.200.40
Functional Family Sphingosine kinase 1

Enzyme Information

2.7.1.91
Sphingosine kinase.
based on mapping to UniProt Q9NYA1
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.
2.3.1.-
Transferring groups other than amino-acyl groups.
based on mapping to UniProt Q9NYA1

UniProtKB Entries (1)

Q9NYA1
SPHK1_HUMAN
Homo sapiens
Sphingosine kinase 1

PDB Structure

PDB 4L02
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Gustin, D.J., Li, Y., Brown, M.L., Min, X., Schmitt, M.J., Wanska, M., Wang, X., Connors, R., Johnstone, S., Cardozo, M., Cheng, A.C., Jeffries, S., Franks, B., Li, S., Shen, S., Wong, M., Wesche, H., Xu, G., Carlson, T.J., Plant, M., Morgenstern, K., Rex, K., Schmitt, J., Coxon, A., Walker, N., Kayser, F., Wang, Z.
Bioorg.Med.Chem.Lett.