CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Serine--pyruvate aminotransferase

Enzyme Information

2.6.1.51
Serine--pyruvate transaminase.
based on mapping to UniProt P21549
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
-!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44
Alanine--glyoxylate transaminase.
based on mapping to UniProt P21549
L-alanine + glyoxylate = pyruvate + glycine.
-!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

P21549
SPYA_HUMAN
Homo sapiens
Serine--pyruvate aminotransferase

PDB Structure

PDB 4KYO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Fodor, K., Wolf, J., Reglinski, K., Passon, D.M., Lou, Y., Schliebs, W., Erdmann, R., Wilmanns, M.
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