CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.230 | Ribosomal Protein S5; domain 2 |
|
3.30.230.10 |
Domain Context
CATH Clusters
| Superfamily | 3.30.230.10 |
| Functional Family |
Enzyme Information
| 5.6.2.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt A0A0J9WZF0
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
|
UniProtKB Entries (1)
| A0A0J9WZF0 |
PARE_FRATH
Francisella tularensis subsp. holarctica LVS
DNA topoisomerase 4 subunit B
|
PDB Structure
| PDB | 4KQV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A new class of type iia topoisomerase inhibitors with
broad-spectrum antibacterial activity
To be Published
|