CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.10210
Functional Family Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Enzyme Information

2.4.2.21
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase.
based on mapping to UniProt Q05603
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
-!- Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate. -!- The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2. -!- It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.

UniProtKB Entries (1)

Q05603
COBT_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

PDB Structure

PDB 4KQF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.
Chan, C.H., Newmister, S.A., Talyor, K., Claas, K.R., Rayment, I., Escalante-Semerena, J.C.
Biochim.Biophys.Acta