1 keywords

CATH Domain 4kprA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.50 3-Layer(bba) Sandwich
Topology 3.50.50 FAD/NAD(P)-binding domain
Homologous Superfamily 3.50.50.60 FAD/NAD(P)-binding domain

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Thioredoxin reductase 1, cytoplasmic

Enzyme Information

1.8.1.9
Thioredoxin-disulfide reductase.
based on mapping to UniProt O89049
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

UniProtKB Entries (1)

O89049
TRXR1_RAT
Rattus norvegicus
Thioredoxin reductase 1, cytoplasmic

PDB Structure

PDB 4KPR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Trp114 residue of thioredoxin reductase 1 is an electron relay sensor for oxidative stress
Xu, J., Eriksson, S.E., Cebula, M., Sandalova, T., Hedstrom, E., Pader, I., Cheng, Q., Myers, C.R., Nagy, P., Hellman, U., Selivanova, G., Lindqvist, Y., J Arner, E.S.
To be Published