CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt O96693
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

O96693
DXR_PLAFX
Plasmodium falciparum HB3
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

PDB Structure

PDB 4KP7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters.
Kunfermann, A., Lienau, C., Illarionov, B., Held, J., Grawert, T., Behrendt, C.T., Werner, P., Hahn, S., Eisenreich, W., Riederer, U., Mordmuller, B., Bacher, A., Fischer, M., Groll, M., Kurz, T.
J.Med.Chem.