CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P9WNX1
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P9WNX1
DYR_MYCTU
Mycobacterium tuberculosis H37Rv
Dihydrofolate reductase

PDB Structure

PDB 4KM2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.
Dias, M.V., Tyrakis, P., Domingues, R.R., Paes Leme, A.F., Blundell, T.L.
Structure