CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cruzipain

Enzyme Information

3.4.22.51
Cruzipain.
based on mapping to UniProt P25779
Broad endopeptidase specificity similar to that of cathepsin L.
-!- Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25779
CYSP_TRYCR
Trypanosoma cruzi
Cruzipain

PDB Structure

PDB 4KLB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Wiggers, H.J., Rocha, J.R., Fernandes, W.B., Sesti-Costa, R., Carneiro, Z.A., Cheleski, J., da Silva, A.B., Juliano, L., Cezari, M.H., Silva, J.S., McKerrow, J.H., Montanari, C.A.
Plos Negl Trop Dis