CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.540
Functional Family

Enzyme Information

3.6.1.15
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt Q27895
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.

UniProtKB Entries (1)

Q27895
NTP2_TOXGO
Toxoplasma gondii
Nucleoside-triphosphatase 2

PDB Structure

PDB 4KH4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base.
Krug, U., Totzauer, R., Zebisch, M., Strater, N.
Chembiochem