CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family DNA gyrase subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P0AES6
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0AES6
GYRB_ECOLI
Escherichia coli K-12
DNA gyrase subunit B

PDB Structure

PDB 4KFG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A new class of type IIA topoisomerase inhibitors with broad-spectrum antibacterial activity
Tari, L.W., Bensen, D.C., Finn, J.
To be Published