CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family Botulinum neurotoxin type A

Enzyme Information

3.4.24.69
Bontoxilysin.
based on mapping to UniProt P10844
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.

UniProtKB Entries (2)

P46097
SYT2_MOUSE
Mus musculus
Synaptotagmin-2
P10844
BXB_CLOBO
Clostridium botulinum
Botulinum neurotoxin type B

PDB Structure

PDB 4KBB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of dual receptor binding to botulinum neurotoxin B.
Berntsson, R.P., Peng, L., Dong, M., Stenmark, P.
Nat Commun