CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Focal adhesion kinase, isoform D

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q05397
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397
FAK1_HUMAN
Homo sapiens
Focal adhesion kinase 1

PDB Structure

PDB 4KAO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-based discovery of focal adhesion kinase inhibitors.
Gradler, U., Bomke, J., Musil, D., Dresing, V., Lehmann, M., Holzemann, G., Greiner, H., Esdar, C., Krier, M., Heinrich, T.
Bioorg.Med.Chem.Lett.