CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P11309
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309
PIM1_HUMAN
Homo sapiens
Serine/threonine-protein kinase pim-1

PDB Structure

PDB 4K0Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Wang, X., Magnuson, S., Pastor, R., Fan, E., Hu, H., Tsui, V., Deng, W., Murray, J., Steffek, M., Wallweber, H., Moffat, J., Drummond, J., Chan, G., Harstad, E., Ebens, A.J.
Bioorg.Med.Chem.Lett.