CATH Domain 4jzvA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family

Enzyme Information

3.6.1.55

8-oxo-dGTP diphosphatase.

based on mapping to UniProt O35013

8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.

-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC 3.6.1.56).

UniProtKB Entries (1)

O35013

YTKD_BACSU

Bacillus subtilis subsp. subtilis str. 168

Putative 8-oxo-dGTP diphosphatase YtkD

PDB Structure

PDB	4JZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates. Piton, J., Larue, V., Thillier, Y., Dorleans, A., Pellegrini, O., Li de la Sierra-Gallay, I., Vasseur, J.J., Debart, F., Tisne, C., Condon, C. Proc.Natl.Acad.Sci.USA