CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor VII

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 4JZE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bolton, S.A., Sutton, J.C., Anumula, R., Bisacchi, G.S., Jacobson, B., Slusarchyk, W.A., Treuner, U.D., Wu, S.C., Zhao, G., Pi, Z., Sheriff, S., Smirk, R.A., Bisaha, S., Cheney, D.L., Wei, A., Schumacher, W.A., Hartl, K.S., Liu, E., Zahler, R., Seiler, S.M.
Bioorg.Med.Chem.Lett.