CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family Polymerase (DNA directed), beta variant

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06746

UniProtKB Entries (1)

P06746
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta

PDB Structure

PDB 4JWN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction.
Batra, V.K., Perera, L., Lin, P., Shock, D.D., Beard, W.A., Pedersen, L.C., Pedersen, L.G., Wilson, S.H.
J.Am.Chem.Soc.