CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.30
Functional Family tRNA (guanine(9)-N1)-methyltransferase

Enzyme Information

2.1.1.221
tRNA (guanine(9)-N(1))-methyltransferase.
based on mapping to UniProt Q12400
S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.
-!- The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9). -!- The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218). -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q12400
TRM10_YEAST
Saccharomyces cerevisiae S288C
TRNA (guanine(9)-N1)-methyltransferase

PDB Structure

PDB 4JWJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., Gong, Q.
Nucleic Acids Res.