CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.30
Functional Family tRNA methyltransferase 10 homolog A

Enzyme Information

2.1.1.221
tRNA (guanine(9)-N(1))-methyltransferase.
based on mapping to UniProt O14214
S-adenosyl-L-methionine + guanine(9) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(9) in tRNA.
-!- The enzyme from Saccharomyces cerevisiae specifically methylates guanine(9). -!- The bifunctional enzyme from Thermococcus kodakaraensis also catalyzes the methylation of adenine(9) in tRNA (cf. EC 2.1.1.218). -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

O14214
TRM10_SCHPO
Schizosaccharomyces pombe 972h-
TRNA (guanine(9)-N1)-methyltransferase

PDB Structure

PDB 4JWH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Shao, Z., Yan, W., Peng, J., Zuo, X., Zou, Y., Li, F., Gong, D., Ma, R., Wu, J., Shi, Y., Zhang, Z., Teng, M., Li, X., Gong, Q.
Nucleic Acids Res.