CATH Domain 4jsrA02

Superfamily	SIR2/SIRT2 'Small Domain'
Functional Family	NAD-dependent deacetylase sirtuin-3, mitochondrial

3.5.1.-

In linear amides.

based on mapping to UniProt Q9NTG7

SIR3_HUMAN

Homo sapiens

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

PDB	4JSR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3. Disch, J.S., Evindar, G., Chiu, C.H., Blum, C.A., Dai, H., Jin, L., Schuman, E., Lind, K.E., Belyanskaya, S.L., Deng, J., Coppo, F., Aquilani, L., Graybill, T.L., Cuozzo, J.W., Lavu, S., Mao, C., Vlasuk, G.P., Perni, R.B. J.Med.Chem.