CATH Classification

Domain Context

CATH Clusters

Superfamily Exonuclease ExoI, domain 2
Functional Family Exodeoxyribonuclease I

Enzyme Information

3.1.11.1
Exodeoxyribonuclease I.
based on mapping to UniProt P04995
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
-!- Preference for single-stranded DNA. -!- The Escherichia coli enzyme hydrolyzes glucosylated DNA. -!- Similar enzymes; mammalian DNase III, exonuclease IV, T2- and T4-induced exodeoxyribonucleases. -!- Formerly EC 3.1.4.25.

UniProtKB Entries (1)

P04995
EX1_ECOLI
Escherichia coli K-12
Exodeoxyribonuclease I

PDB Structure

PDB 4JS5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of Escherichia coli exonuclease I in complex with single-stranded DNA provide insights into the mechanism of processive digestion.
Korada, S.K., Johns, T.D., Smith, C.E., Jones, N.D., McCabe, K.A., Bell, C.E.
Nucleic Acids Res.