CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Beta-lactamase

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P9WKD3
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P9WKD3
BLAC_MYCTU
Mycobacterium tuberculosis H37Rv
Beta-lactamase

PDB Structure

PDB 4JLF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Kurz, S.G., Wolff, K.A., Hazra, S., Bethel, C.R., Hujer, A.M., Smith, K.M., Xu, Y., Tremblay, L.W., Blanchard, J.S., Nguyen, L., Bonomo, R.A.
Antimicrob.Agents Chemother.