CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.230
Functional Family Pre-mRNA-processing-splicing factor 8

Enzyme Information

UniProtKB Entries (1)

Q6P2Q9
PRP8_HUMAN
Homo sapiens
Pre-mRNA-processing-splicing factor 8

PDB Structure

PDB 4JKF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Schellenberg, M.J., Wu, T., Ritchie, D.B., Fica, S., Staley, J.P., Atta, K.A., Lapointe, P., Macmillan, A.M.
Nat.Struct.Mol.Biol.