CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.150
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8V2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0A7Z4
RPOA_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 4JK1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Differential regulation by ppGpp versus pppGpp in Escherichia coli.
Mechold, U., Potrykus, K., Murphy, H., Murakami, K.S., Cashel, M.
Nucleic Acids Res.