CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9DC28
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26
[Tau protein] kinase.
based on mapping to UniProt Q9DC28
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.

UniProtKB Entries (1)

Q9DC28
KC1D_MOUSE
Mus musculus
Casein kinase I isoform delta

PDB Structure

PDB 4JJR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A monoclinic crystal form of casein kinase 1 delta
Zeringo, N.A., Murphy, L., McCloskey, E.A., Rohal, L., Bellizzi, J.J.
Acta Crystallogr.,Sect.F