CATH Classification

Domain Context

CATH Clusters

Superfamily Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family Ubiquitin carboxyl-terminal hydrolase 7

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q93009
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q93009
UBP7_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

PDB 4JJQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1.
Sarkari, F., Wheaton, K., La Delfa, A., Mohamed, M., Shaikh, F., Khatun, R., Arrowsmith, C.H., Frappier, L., Saridakis, V., Sheng, Y.
J. Biol. Chem.