CATH Classification

Domain Context

CATH Clusters

Superfamily Domain 2, N(10)-formyltetrahydrofolate synthetase
Functional Family Formate--tetrahydrofolate ligase

Enzyme Information

6.3.4.3
Formate--tetrahydrofolate ligase.
based on mapping to UniProt Q2RM91
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
-!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.

UniProtKB Entries (1)

Q2RM91
FTHS_MOOTA
Moorella thermoacetica ATCC 39073
Formate--tetrahydrofolate ligase

PDB Structure

PDB 4JIM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of N10-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.
Celeste, L.R., Chai, G., Bielak, M., Minor, W., Lovelace, L.L., Lebioda, L.
Protein Sci.