CATH Classification

Domain Context

CATH Clusters

Superfamily Peptide deformylase
Functional Family Peptide deformylase

Enzyme Information

3.5.1.88
Peptide deformylase.
based on mapping to UniProt Q9FV53
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide.
-!- Requires at least a dipeptide for an efficient rate of reaction. -!- N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. -!- Differs in substrate specificity from EC 3.5.1.27 and EC 3.5.1.31.

UniProtKB Entries (1)

Q9FV53
DEF1A_ARATH
Arabidopsis thaliana
Peptide deformylase 1A, chloroplastic/mitochondrial

PDB Structure

PDB 4JE8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Understanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpart.
Fieulaine, S., Desmadril, M., Meinnel, T., Giglione, C.
Acta Crystallogr.,Sect.D