CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family Polymerase (DNA directed), eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q9Y253
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q9Y253
POLH_HUMAN
Homo sapiens
DNA polymerase eta

PDB Structure

PDB 4J9M
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta.
Zhao, Y., Gregory, M.T., Biertumpfel, C., Hua, Y.J., Hanaoka, F., Yang, W.
Proc.Natl.Acad.Sci.USA