CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Sepiapterin reductase

Enzyme Information

1.1.1.153
Sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
based on mapping to UniProt P35270
(1) L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPH. (2) L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8- tetrahydropterin + 2 NADPH.
-!- This enzyme catalyzes the final step in the de novo synthesis of tetrahydrobiopterin from GTP. -!- The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. -!- Cf. EC 1.1.1.325.

UniProtKB Entries (1)

P35270
SPRE_HUMAN
Homo sapiens
Sepiapterin reductase

PDB Structure

PDB 4J7U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Haruki, H., Pedersen, M.G., Gorska, K.I., Pojer, F., Johnsson, K.
Science