CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family N-acyl homoserine lactonase AiiA

Enzyme Information
Quorum-quenching N-acyl-homoserine lactonase.
based on mapping to UniProt A3FJ64
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
-!- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. -!- Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes. -!- Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria. -!- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.

UniProtKB Entries (1)

Bacillus thuringiensis
N-acyl homoserine lactonase

PDB Structure

External Links
Primary Citation
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis.
Liu, C.F., Liu, D., Momb, J., Thomas, P.W., Lajoie, A., Petsko, G.A., Fast, W., Ringe, D.