CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P30405
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P30405
PPIF_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

PDB Structure

PDB 4J5D
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Ahmed-Belkacem, A., Colliandre, L., Ahnou, N., Nevers, Q., Gelin, M., Bessin, Y., Brillet, R., Cala, O., Douguet, D., Bourguet, W., Krimm, I., Pawlotsky, J.M., Guichou, J.F.
Nat Commun