CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1360.40
Functional Family DNA topoisomerase 2

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q02880
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

Q02880
TOP2B_HUMAN
Homo sapiens
DNA topoisomerase 2-beta

PDB Structure

PDB 4J3N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs
Wu, C.C., Li, Y.C., Wang, Y.R., Li, T.K., Chan, N.L.
Nucleic Acids Res.