CATH Domain 4j3fE00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Enoyl-[acyl-carrier-protein] reductase [NADH]

Enzyme Information

UniProtKB Entries (1)

Q5NGQ3_FRATT

Francisella tularensis subsp. tularensis SCHU S4

Enoyl-[acyl-carrier-protein] reductase [NADH]

PDB Structure

PDB	4J3F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Mehboob, S., Song, J., Hevener, K.E., Su, P.C., Boci, T., Brubaker, L., Truong, L., Mistry, T., Deng, J., Cook, J.L., Santarsiero, B.D., Ghosh, A.K., Johnson, M.E. Bioorg.Med.Chem.Lett.