CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic transduction domain A
Functional Family Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Enzyme Information

7.2.2.10
P-type Ca(2+) transporter.
based on mapping to UniProt P04191
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
-!- A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum, in yeast, and in some bacteria. -!- The enzymes from plasma membrane and from yeast have been shown to transport one ion per ATP hydrolyzed whereas those from the sarcoplasmic reticulum transport two ions per ATP hydrolyzed. -!- In muscle cells Ca(2+) is transported from the cytosol into the sarcoplasmic reticulum. -!- Formerly EC 3.6.1.38 and EC 3.6.3.8.

UniProtKB Entries (1)

P04191
AT2A1_RABIT
Oryctolagus cuniculus
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB 4J2T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase.
Paulsen, E.S., Villadsen, J., Tenori, E., Liu, H., Bonde, D.F., Lie, M.A., Bublitz, M., Olesen, C., Autzen, H.E., Dach, I., Sehgal, P., Nissen, P., Moller, J.V., Schiott, B., Christensen, S.B.
J.Med.Chem.