CATH Domain 4j1yA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement C1s subcomponent

Enzyme Information

3.4.21.42

Complement subcomponent C1s.

based on mapping to UniProt P09871

Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.

-!- Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P09871

C1S_HUMAN

Homo sapiens

Complement C1s subcomponent

PDB Structure

PDB	4J1Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. Perry, A.J., Wijeyewickrema, L.C., Wilmann, P.G., Gunzburg, M.J., D'Andrea, L., Irving, J.A., Pang, S.S., Duncan, R.C., Wilce, J.A., Whisstock, J.C., Pike, R.N. J.Biol.Chem.