CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Transmembrane serine protease 7

Enzyme Information

3.4.21.109
Matriptase.
based on mapping to UniProt Q9Y5Y6
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.
-!- This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. -!- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF. -!- Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q9Y5Y6
ST14_HUMAN
Homo sapiens
Suppressor of tumorigenicity 14 protein

PDB Structure

PDB 4IS5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
Zhao, B., Yuan, C., Li, R., Qu, D., Huang, M., Ngo, J.C.
J.Biol.Chem.