CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family |
Enzyme Information
| 1.1.1.395 |
3-alpha-hydroxybile acid CoA 3-dehydrogenase.
based on mapping to UniProt P19337
A 3-alpha-hydroxy bile acid CoA ester + NAD(+) = a 3-oxo bile acid CoA ester + NADH.
-!- This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. -!- The enzyme has very little activity with unconjugated bile acid substrates. -!- It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA. -!- Formerly EC 1.17.98.1.
|
UniProtKB Entries (1)
| P19337 |
BAIA2_CLOSV
[Clostridium] scindens
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2
|
PDB Structure
| PDB | 4IS3 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 in complex with a putative NAD(+)-OH- adduct at 2.0 A resolution
To be published
|