CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.395
3-alpha-hydroxybile acid CoA 3-dehydrogenase.
based on mapping to UniProt P19337
A 3-alpha-hydroxy bile acid CoA ester + NAD(+) = a 3-oxo bile acid CoA ester + NADH.
-!- This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. -!- The enzyme has very little activity with unconjugated bile acid substrates. -!- It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA. -!- Formerly EC 1.17.98.1.

UniProtKB Entries (1)

P19337
BAIA2_CLOSV
[Clostridium] scindens
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2

PDB Structure

PDB 4IS2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the apo form of a 3alpha-hydroxysteroid dehydrogenase (BaiA2) associated with secondary bile acid synthesis from Clostridium scindens VPI12708 at 1.90 A resolution
Joint Center for Structural Genomics (JCSG)
To be published