CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase IV

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q47155
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q47155
DPO4_ECOLI
Escherichia coli K-12
DNA polymerase IV

PDB Structure

PDB 4IR1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli.
Sharma, A., Kottur, J., Narayanan, N., Nair, D.T.
Nucleic Acids Res.