CATH Classification

Domain Context

CATH Clusters

Superfamily 2.40.50.100
Functional Family DNA-directed RNA polymerase subunit beta

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8T7
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P0A8T7
RPOC_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit beta'

PDB Structure

PDB 4IQZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystal structure of a large insert in RNA polymerase (RpoC) subunit from E. coli
Bhandari, V., Sugiman-Marangos, S.N., Naushad, H.S., Gupta, R.S., Junop, M.S.
To be Published