CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family DNA polymerase lambda

Enzyme Information

3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P09838
2.7.7.31
DNA nucleotidylexotransferase.
based on mapping to UniProt P09838
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Nucleoside may be ribo- or deoxyribo-.

UniProtKB Entries (1)

P09838
TDT_MOUSE
Mus musculus
DNA nucleotidylexotransferase

PDB Structure

PDB 4IQU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
Costi, R., Cuzzucoli Crucitti, G., Pescatori, L., Messore, A., Scipione, L., Tortorella, S., Amoroso, A., Crespan, E., Campiglia, P., Maresca, B., Porta, A., Granata, I., Novellino, E., Gouge, J., Delarue, M., Maga, G., Di Santo, R.
J.Med.Chem.