CATH Classification

Domain Context

CATH Clusters

Superfamily Kelch-type beta propeller
Functional Family Kelch-like ECH-associated protein 1

Enzyme Information

UniProtKB Entries (1)

Q14145
KEAP1_HUMAN
Homo sapiens
Kelch-like ECH-associated protein 1

PDB Structure

PDB 4IQK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Marcotte, D., Zeng, W., Hus, J.C., McKenzie, A., Hession, C., Jin, P., Bergeron, C., Lugovskoy, A., Enyedy, I., Cuervo, H., Wang, D., Atmanene, C., Roecklin, D., Vecchi, M., Vivat, V., Kraemer, J., Winkler, D., Hong, V., Chao, J., Lukashev, M., Silvian, L.
Bioorg.Med.Chem.