CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt P28845
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

P28845
DHI1_HUMAN
Homo sapiens
Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB 4IJW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1).
Li, J., Kennedy, L.J., Wang, H., Li, J.J., Walker, S.J., Hong, Z., O'Connor, S.P., Nayeem, A., Camac, D.M., Morin, P.E., Sheriff, S., Wang, M., Harper, T., Golla, R., Seethala, R., Harrity, T., Ponticiello, R.P., Morgan, N.N., Taylor, J.R., Zebo, R., Gordon, D.A., Robl, J.A.
ACS Med Chem Lett