CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.2020 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.2020 |
| Functional Family | Hypoxanthine phosphoribosyltransferase |
Enzyme Information
| 2.4.2.8 |
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
|
UniProtKB Entries (1)
| P00492 |
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase
|
PDB Structure
| PDB | 4IJQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity
J.Med.Chem.
|