CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family 2'-5'-oligoadenylate synthetase 1

Enzyme Information

2.7.7.84
2'-5' oligoadenylate synthase.
based on mapping to UniProt P00973
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.
-!- The enzyme is activated by binding to double-stranded RNA. -!- The resulting product binds to and activates RNase L, which subsequently degrades the RNA. -!- Oligoadenylates of chain lengths 2, 4 and 5 are also produced. -!- The dimer does not have any known biological activity.

UniProtKB Entries (1)

P00973
OAS1_HUMAN
Homo sapiens
2'-5'-oligoadenylate synthase 1

PDB Structure

PDB 4IG8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1.
Donovan, J., Dufner, M., Korennykh, A.
Proc.Natl.Acad.Sci.USA