CATH Domain 4ig6A02
|1.10.1270||Trp Operon Repressor; Chain A|
|1.10.1270.20||tRNA(m1g37)methyltransferase, domain 2|
|Superfamily||tRNA(m1g37)methyltransferase, domain 2|
based on mapping to UniProt Q2GIL5
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 188.8.131.52.
UniProtKB Entries (1)
Anaplasma phagocytophilum str. HZ
Crystal structure of a tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum bound to S-adenosylhomocysteine
TO BE PUBLISHED